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The study reveals that firing pattern influences the effective spacing to burden ratio at the time of detonation.
Input variables were: joints spacing, density and uniaxial compressive strength of the intact rock, burden, spacing, stemming, bench height to burden ratio, and specific charge.
By changing the firing pattern, effective burden (Be) changes and the ratio of effective spacing (Se) to effective burden (Be) during the firing is also subject to change in comparison to drilled spacing to burden ratio (S/B).
The burden ratio is clearly a crude statistic and is prone to misuse.
The mutational burden ratio of JAK2 was calculated using the DNA and RNA copy numbers according to the following formula: JAK2V617F/ JAK2V617F + JAK2WT).
First, any systematic batch effects that bias the intensity for cases or controls can easily manifest itself in the burden ratio, which we observed for test runs when PC correction was not applied to the LRR data.
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Employers should keep an eye on these burden ratios.
The comparisons of the DNA or RNA JAK2V617F mutational burden ratios showed significant differences whether they were calculated at the DNA or RNA level.
There was a marked trend that less stringent configurations produced large positive burden ratios (for instance, between 1.2 and 3.0), while more stringent configurations led to an overall burden close to unity, and higher quality scores.
The main exception to the improvement in allocation to burden ratios appears to be breast cancer, for which large decreases in proportional YLL over the past decade are paired with increases in proportional research funding.
At the DNA level, ET patients showed significantly lower JAK2V617F allele burden ratios as compared to both PV and PMF (22%% vs. 45%% and vs. 47 %, respectively [ET vs. PV p = 0.01; ET vs. PMF p = 0.02]) whereas, at the RNA level, significant differences were recorded only between ET and PMF patient groups (56 vs. 80 %; p = 0.03) (Fig. 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com