Headache in the preceding year was reported by 1,488 participants (63.9 %; 621 male, 867 female), along with attributable symptom burden in terms of frequency and intensity.
We measured symptom burden in terms of frequency (days/month), intensity (with response options "not bad", "quite bad" and "very bad", which we interpreted as mild, moderate and severe) and duration (hours).
The burden of very rare (frequency <1/1000) variants in CFI was strongly associated with disease (P = 1.1 × 10−8).
The distribution of different CAM treatments is displayed in Table 4. a not applicable b (e.g. diets, music therapy, oxygen therapy, psychofonia, meditation, climate therapy); n The relationship between the burden of disease and frequency of CAM use was calculated.
However, sustaining the benefits of early treatment requires lifelong adherence to cART, which is hampered by dependence on caregivers for cART administration, poor palatability of drugs, pill burden and frequency of administration, drug toxicities and developmental changes, especially during adolescence [ 8– 10].
Many studies reported only prevalence; some reported symptom burden (usually in terms of frequency, intensity and duration); some included limited enquiry into functional impact (commonly using the migraine disability assessment (MIDAS) questionnaire [127]).
The increasing noncommunicable disease burden and frequency of natural disasters across the world has created an immediate need to implement strategies for reducing the risk of indirect mortality and morbidity post disaster.
Also, the relatively small sample size makes it inadequate to control for variables such as medications, seizure burden and frequency of discharges across patients.
Although there have been advances in treatment options that have reduced pill burden and frequency of dosing, the need for daily dosing poses challenges for long term adherence.
Symptom burden was expressed in terms of frequency, intensity and duration.
