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Biomaterials for tissue engineering that recapitulate the mechanical response and biological function of native tissue are highly sought after to lessen the burden of damaged or diseased tissue.
The autophagy activity of living cells increases with age and is due to an increased intracellular burden of damaged macromolecules and organelles caused by reactive oxygen species during aging [29].
To link increased DNA-PKcs expression with the cellular burden of damaged DNA, TMs and DNA-PKcs transcript concentrations were compared in individual T-cell samples (Fig 3D).
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In the subgroup of individuals with schizophrenia, using biologically informed filters revealed a greater burden of damaging variants affecting protein-coding genes involved in neuron projection (axonal and dendritic development), a gene-set previously implicated in schizophrenia using other approaches (Costain et al. 2013; Merico et al. 2014).
Judges have recognized that many of those returning from war are carrying a heavy burden of damage that might not be physically visible.
In contrast, when growth is barely possible, it is possible that an overall burden of damages matters, rather than single mutations, and the phenotypic reaction may be more threshold-like than incremental.
As the brain ages, it would likely struggle to cope with the heavy burden of degrading damaged cellular components and making repairs, particularly in the presence of a misfolded protein.
The financial burden has damaged the global competitiveness of American businesses and bankrupted millions of families, even those with insurance.
The originally documented axonal protection was not only eliminated by this rapid rewarming but, in fact, the overall burden of axonal damage was dramatically increased, reaching a virtual doubling of the numbers of damaged axons seen per unit area [ 3].
"Usually the decision will say they were acting within the scope of their official duties and therefore the municipality will bear the burden of the damages".
Demographic aging is a worldwide phenomenon, cognitive and behavioral impairment is becoming global burden of nerve damage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com