In contrast, when growth is barely possible, it is possible that an overall burden of damages matters, rather than single mutations, and the phenotypic reaction may be more threshold-like than incremental.
In the subgroup of individuals with schizophrenia, using biologically informed filters revealed a greater burden of damaging variants affecting protein-coding genes involved in neuron projection (axonal and dendritic development), a gene-set previously implicated in schizophrenia using other approaches (Costain et al. 2013; Merico et al. 2014).
Demographic aging is a worldwide phenomenon, cognitive and behavioral impairment is becoming global burden of nerve damage.
The originally documented axonal protection was not only eliminated by this rapid rewarming but, in fact, the overall burden of axonal damage was dramatically increased, reaching a virtual doubling of the numbers of damaged axons seen per unit area [ 3].
But today's educators carry the burden of the damage it did to teaching and learning.
34 With aging, cells accumulate a progressively larger burden of mtDNA damage, which is preferentially, clonally amplified within cells.
Given the current paucity of neurotherapeutic strategies for excitotoxic injuries in the perinatal and pediatric population, these data suggest that HIP/PAP might have clinical potential to reduce the burden of neurological damage associated with these injuries.
If a patient survives infarction (due to medical intervention), she can live for many years, reflecting the fact that catastrophe was not due to the burden of molecular damage.
With a large burden of genetic damage naturally accruing as we age, there are many mechanisms that have evolved to prevent these from resulting in fatal cancers and it is now clear that for a cancer to develop there are a number of essential controls that have to be overcome.
"Usually the decision will say they were acting within the scope of their official duties and therefore the municipality will bear the burden of the damages".
