Reduction after an initial increase in tumor burden; this observation has been associated with T-cell infiltration into the tumor, giving the appearance of progressive disease.
Although the addition of CYT387 with paclitaxel resulted in the significant reduction of tumor burden, an observation using a minimum of three mice in all treatment groups revealed no difference in the invasion pattern in all treatment regimens (images for pancreas and liver presented in Additional file 3: Figure S3.
Differential species burden patterns observed were not surprising as similar observations have been reported elsewhere [ 14, 23].
I'm thoroughly disgusted that I alone must bear the burden of my observations.
This was not unexpected, given the fact that patients with NYHA class I/II heart failure had a smaller symptom burden and the observation time for such improvements needs to be longer than 6 months.
Importantly, when the two drugs were combined, only very low dosages of both were needed to cause meaningful reduction in tumor burden, a significant observation for the clinical setting to minimize toxicity.
Similar in solving ( {mathcal{P}}_1 ), the computational complexity of solving ( {mathcal{P}}_2 ) depends exponentially on the observation number N, as well as the complexity burden required at each observation, i.e., the maximum point search algorithm used for parameters.
There is a technology-associated burden, indicated by our observation that even without cost barriers most participants chose not to use real-time sensors 100% of their availability.
Such considerations will be particularly important where resource constraints or patient burden preclude the direct observation of preference-based measures in the trial population.
In addition to a confirmation of what we would expect qualitatively for the healthcare burden of influenza, our observation provides a useful quantitative estimate for these effects in the general population.
