Sentence examples for burden in the brain from inspiring English sources
While the peptide-modified AAV reversed cognitive deficits, improved storage burden in the brain, and substantially prolonged survival, we were surprised to find that AAV9 provided no CNS benefit.
PET radiopharmaceuticals capable of imaging β-amyloid (Aβ) plaque burden in the brain could offer highly valuable diagnostic tools for clinical studies of Alzheimer's disease.
Using a three-dimensional human stem cell-derived neural culture system he created, Tanzi is also developing therapeutics for Alzheimer's including gamma secretase modulators and metal chaperones to lower beta-amyloid and tangle burden in the brain.
In an experimental model of brain metastases of breast cancer, cytotoxic concentrations of paclitaxel were reached only in a subset (<10 %) of the "leakiest" metastases (Lockman et al. 2010), and this therapy was unable to reduce the metastatic burden in the brain over the period of the study.
Compared to other C5-deficient strains, infected AKR/J strain displays a reduced fungal burden in the brain, heart and kidney, and increased survival, concomitant with uniquely high levels of serum IFNγ.
This was accompanied by a reduction in parasite burden in the brain.
We utilized isochronic parabiosis to test the efficacy of peripheral clearance of Aβ in alleviating the amyloid burden in the brains of APPswe/PS1dE9 transgenic mice.
Several studies examining the effect of resveratrol in vivo found that this compound reduced the plaque burden in the brains of transgenic mice overexpressing APP.
In a similar study, McConlogue and colleagues reported a significantly reduced Aβ burden in the brains of 13-month-old and 18-month-old PDAPP BACE1 +/- mice [ 62].
We next investigated whether the decrease in Aβ burden in the brains of 5XFAD mice that had been treated with triptolide was mediated by decreased Aβ production or increased Aβ clearance.
These findings are relevant for the design of future clinical trials aimed at the prevention of progression to AD by lowering the Aβ burden in the brains of patients with MCI.
