Sentence examples for burden in models of from inspiring English sources

Similarly, identification of tumors and quantification of tumor burden in models of metastasis demand exhaustive and tedious histological analyses[6], [7], [8].

Mark demonstrated that these 'nanosolutions' reduce in vivo tumor burden in models of hepatocellular carcinoma (HCC), and breast/pancreatic/melanoma cancer as well as leukemias.

RCNV treatment also prolonged survival in treatment-resistant models of brain tumors and decreased tumor burden by systemic administration in models of lung metastasis.

As a consequence, OPG is capable of inhibiting bone destruction and reducing skeletal tumor burden in animal models of breast cancer bone metastasis [ 3, 8].

Minnelide has been shown to reduce tumor burden in preclinical models of osteosarcoma [ 11].

Pre-clinical data have shown that the cathepsin K inhibitor AFG-495 reduced bone destruction and skeletal tumor burden in animal models of breast cancer bone metastasis [ 27].

Upscaling of conductivity in models of aquifer flow is needed in order to reduce the numerical burden, especially when modeling flow in heterogeneous aquifers of 3D random structure.

Treatment of mice with an anti-LOXL2 monoclonal antibody reduced the fibrotic burden in a model of cancer and lung fibrosis, in part via reduction in disease-associated fibroblasts.

Indeed, chronic (∼30 weeks) topical application of small quantities (40 nmol per animal) of TBE-31 twice a week resulted in dramatically reduced tumor multiplicity and burden in a model of ultraviolet radiation-mediated skin carcinogenesis in SKH-1 hairless mice receiving azathioprine treatment [19].

For example, multiple Aβ antibodies were shown to reduce Aβ burden in preclinical models and several of them have progressed to clinical trials for treating AD patients (Lemere and Masliah, 2010).

Different techniques have been described to monitor the MM burden in animal models, such as fluorescent tagging of tumor cells [ 40- 45] or measurement of MM-derived paraptrotein in the serum [ 29- 32].