Sentence examples for burden in a mouse from inspiring English sources

More importantly, the hybrid 7 also showed very low cytotoxicity, and could significantly reduce the mycobacterial burden in a mouse model infected with autoluminescent H37Ra strain, which may serve as a lead compound for further development of new anti-tubercular agents.

THZ significantly reduces bacterial burden in a mouse model of TB [19] and shows promising activity in a mouse model of MDR-TB.

Importantly, neutralizing monoclonal antibodies raised against the mouse α4 integrin subunit also decreased osteolysis and overall tumor burden in a mouse model of myeloma bone disease [ 19].

Inhibition of osteoclast activity by a variety of different factors has shown to decrease tumor burden in a mouse breast cancer bone metastasis model [ 37].

Moreover, in several human malignant cell types, including lymphoma, melanoma, fibrosarcoma, and squamous cell carcinoma, T-oligos induce differentiation, apoptosis and/or senescence [ 9, 13, 17], and strikingly reduce tumor burden in a mouse xenograft model of human melanoma [ 13].

Recently, it has been shown that two members of the neprilysin family cleave the Alzheimer's amyloid β-peptide (Aβ) in the mammalian brain and that ex-vivo expression of neprilysin reduces amyloid plaque burden in a mouse model [ 3].

PRL-3 antibody therapy reduced tumour burden in a leukaemia mouse model.

Further testing showed that a mere two infusions with GSK2857916 achieved complete eradication of tumor burden in a xenograft mouse model.

Eggs were allowed to embryonate for at least six weeks in dH2O and infectivity established by worm burden in a susceptible mouse strain.

In addition, loss of HDAC6 restored cognitive function without impacting Aβ plaque burden in a transgenic mouse model of AD (12), and also rescued the abnormal behavioral phenotype in a Drosophila model of tauopathy (13).

Interestingly, Efstathiou et al. have found that a treatment with non-steroidal anti-inflammatory drugs (NSAIDs) also reduces disease burden in an endometriosis mouse model.