Such straightforward schedules allow simplifying data collection logistics, but may also have an impact on the collected PRO scores as symptom burden, functioning, and quality of life (QOL) may not be assessed at time points giving the most appropriate picture of their longitudinal development.
For the Social Functioning, Vitality, Treatment Burden, and Role Functioning scales, the ivacaftor group included three to five times more patients with improvements compared to placebo.
In order to alleviate the computation burden, score function together with the MCS method is exploited to compute the stochastic sensitivities of reliability functions.
The effects of suppressing emotions and motor activities burden the function of an organism resulting in several neuromuscular disorders [ 32].
We live in a world which values the useless ahead of the useful, which celebrates art, untainted by the least hint of utility, above the ingenuity of design that is burdened by function, and creates a cultural hierarchy to match.
These women reported greater headache impact and migraine-related burden on functioning than those in whom migraines were not related to menstruation.
Our study showed that in CT outpatients patient-reported symptom burden and functioning impairments are most severe one week after CT administration.
As a measure of changes in symptom burden or functioning, we provide monthly change rates for the EORTC QLQ-C30 scales, i.e., change in score points per 30 days.
This 39-item self-administered instrument measures patients' self-assessed quality of life, and includes 5 domains: diabetes control, anxiety and worry, social burden, sexual functioning, and energy and mobility.
To compare the symptom burden and functioning between patients in different chemotherapy lines, we used mixed linear models, including the following terms: a random baseline, a first-order autocorrelation covariance matrix, and a main effect patient group (chemotherapy line).
