Creation of bispecific antibody from four individual amino acid sequences (different light and heavy chains) is a process which must be optimized to minimize burden on downstream processing.
The nicotine level in tobacco leaves, for example, is three times that in the roots (Dawson and Solt, 1959), thus potentially posing a greater burden on downstream processing.
Our conclusions support the notion that principled feature-based machine learning classification frameworks will be well placed to leverage evolving trends in the cancer NGS field, thereby reducing the burden of downstream validation efforts with more accurate predictions.
Increasing the speed at which low-risk and non-emergent patients are identified will reduce downstream burdens, freeing up time for emergency physicians to spend on more critically ill or time-sensitive patients.
However, the addition of osmoregulators would burden the separation of downstream.
Although ADE, alone, is not sufficient to explain the vascular pathology associated with DHF since many individuals also experience DHF during primary infection, it can explain antibody-dependent increases in viral uptake and infection burden that could promote downstream pathogenesis (St John et al., 2013a).
Motivation: Accurate alignment of large numbers of sequences is demanding and the computational burden is further increased by downstream analyses depending on these alignments.
Childhood obesity and its downstream effects are burdening our kids' and humanity's future.
44 These complications will lead to an increased demand for healthcare assistance and an unnecessary downstream of financial burdens.
PCBs from these upriver sources were transported downriver and resulted in an inverse concentration gradient between levels of contaminants in Hudson River sediments, as well as tissue burdens in fishes, and distance downstream.
