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Parallel design studies for device atrial fibrillation (AF) burden and frequency endpoints were found to be of little value because they would require thousands of patients.
The increasing noncommunicable disease burden and frequency of natural disasters across the world has created an immediate need to implement strategies for reducing the risk of indirect mortality and morbidity post disaster.
Each profile had a predefined range of attributes: blood glucose control, frequency of mild-to-moderate hypoglycaemia, annual severe hypoglycaemic events, annual weight gain, pill burden and frequency of administration, and cost.
Also, the relatively small sample size makes it inadequate to control for variables such as medications, seizure burden and frequency of discharges across patients.
Although there have been advances in treatment options that have reduced pill burden and frequency of dosing, the need for daily dosing poses challenges for long term adherence.
In order to perform these reviews the following keywords were used: "Lupus Erythematosus, Systemic" [Mesh], LES, "Epidemiology" [Mesh], incidence, prevalence, burden, and frequency.
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Factors such as work load and frequency of lifted burdens may play an important role.
The relationship between overall interictal burden and headache frequency is likely to be complex; burden may be heavier with higher frequency, but it is not borne for so long.
ART regimens are now simpler than they were in the past, with lower pill burden and dosing frequency; they have also become less toxic and better tolerated [ 4].
Also, in line with previously published reports [ 8, 18], high baseline CTC counts were associated with greater metastatic tumor burden and higher frequency of bone involvement (Table 1).
Treatment regimen characteristics associated with shorter persistence include efficacy, tolerability profile, and regimen complexity (e.g., higher pill burden and dosing frequency; Panel on Antiretroviral Guidelines for Adults and Adolescents, 2009; Elzi et al., 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com