But it rejected one idea that might actually have provided a way to reduce Greece's overall debt burden: allowing the European stabilization fund to buy up Greek bonds on the open market, where they are trading at a big discount to their notional value.
Mr. Issing contends that the owners of Greece's debt should be required to take a roughly 50 percent write-down on their holdings as part of an "orderly" default that would reduce Greece's overall debt burden, allowing it to meet its obligations without further borrowing.
Subsequently, as the drug sensitive population of bacteria dwindles, the mutant population grows to high burden allowing the occurrence of mutations to a second drug; ensuing exposure to that drug now selects for doubly resistant bacilli.
The reduction in tumour burden allows the vessels to recover.
Secondly, this reduction in the viral burden allows patients' own homeostatic mechanisms to replenish the CD4 T-cell pool.
Being able to easily and reliably measure the morbidity burden allows decision makers to identify and fairly reimburse physicians whose patients have a higher burden of illness.
This "compliance burden" allows for an exploration of whether certain groups or communities have unequal abilities in the capacity to meet the standard.
One potential strategy to help those people with pathology and cognitive decline is to remove the pathological burden allowing the brain to function more efficiently.
It minimises respondent burden, allows rapid feedback and comparisons to be made between different care settings either within an organisation or across the patient pathway.
The NMDAS, as a quantitative measure of mitochondrial disease burden, allows us to study disease progression with unprecedented power, and longitudinal modelling of successive NMDAS assessments for patients demonstrates the benefits of such an approach.
