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Impairment of the actin-bundle turnover was demonstrated in neuronal growth-cones upon pharmacological inhibition of myosin II motor activity [6].
These myriad actin binding proteins regulate numerous functions such as filament nucleation, bundling, cross-linking, anchoring, turnover, and cargo transport to name a few.
The staircase-like organization of the stereocilia bundle is dynamically maintained by variable actin turnover rates.
Each subunit is composed of a haem-nitric oxide binding domain, a PAS-like domain, a coiled-coil bundle, and the C-terminal catalytic domain where turnover of GTP into cGMP occurs.
Broadwing bundles in local cell service and has reduced customer turnover to 1% a month, less than half the industry average.
Actin cables are composed of bundles of short actin filaments [52] and these short actin filaments undergo continuous turnover in yeast [20].
However, such a massive domain movement is difficult to reconcile with the high turnover rates of EcNhaA and the comparatively subtle substrate-induced changes in and around the 6-helix bundle we observe experimentally in MjNhaP1.
Signature components of the lamellipodium include Arp2/3 and ADF/cofilin, involved in formation and turnover of branching actin network, while the lamellum contains tropomyosin and myosin II, proteins characteristic of contractile bundles of actin filaments.
A bundle.
Why bundle?
Fans better bundle up.
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Justyna Jupowicz-Kozak
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