Sentence examples for bundle development from inspiring English sources
The initial formation of normal stereocilia in p.E1086X mutants suggests that isoform 2 is sufficient for normal hair bundle development, consistent with our finding that the dominant Myo15 transcript in developing P0 hair cells encodes isoform 2. Conversely, the postnatal switch to isoform 1 expression points to a distinct function for myosin 15 that is also essential for normal hearing.
By comparing different sizes of stems in P. betle (Fig. 2a d) and P. kadsura (Fig. 2e h), two different series of vascular bundle development were observed.
The levels of myosinXVa at the stereocilia tips are correlated with stereocilia lengths from the early embryonic stages of bundle development [2].
Together, these results confirm a requirement for harmonin in hair bundle development.
It follows that isoform 1 has a function critical for hearing that is unrelated to stereocilia bundle development.
Unconventional myosin 15 (encoded by Myo15) is an actin-based molecular motor and a key regulator of hair bundle development.
In an effort to determine a possible role for fascin 2b in hair-bundle development, we used morpholino oligomers [44] to knockdown the production of this protein in zebrafish embryos.
Some anastomoses exist already at early stages of primary phloem fibre-bundle development as evident by the parenchyma cells that are present within the young bundles (Fig. 3).
Conditional post-natal deletion of exon 38, specific to the Pcdh15-CD2 isoform, circumvented the early morphogenetic defects caused by the absence of this isoform during hair-bundle development (Webb et al, 2011; see Methods and Supplementary Fig S4).
By immunolabelling and both morphological and electrophysiological analyses of post-natal hair cell-specific conditional knockout mice (Pcdh15ex38-fl/ex38-fl Myo15- cre+/−) that lose only this isoform after normal hair-bundle development, we show that Pcdh15-CD2 is an essential component of tip-links in mature auditory hair cells.
There are three Pcdh15 splice isoforms (CD1, CD2 and CD3), which only differ by their cytoplasmic domains; they are thought to function redundantly in mechano-electrical transduction during hair-bundle development, but whether any of these isoforms composes the tip-link in mature hair cells remains unknown.
