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The area marked "bundle cost-effective" shows combinations of cost and effectiveness for the bundle at which total costs increase but the cost per QALY is less than $64,000.
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These are the bundles at which Crusoe's and Friday's Marginal rate of substitution are equal.
In [55], nodes use a migration algorithm to transfer bundle to nodes at which less congestion occurs.
The maximum cost for the bundle was identified at which it would remain cost-effective assuming it would reduce risk of CR-BSI by RR CR-BSI 0.34.
Given uncertainty about the cost of the bundle, threshold analyses were used to determine the maximum cost at which the bundle remained cost-effective relative to the other approaches to infection control.
The area marked "bundle cost-saving" on each graph indicates combinations of cost and effectiveness at which the bundle reduces total costs and delivers extra health benefits relative to the comparator.
The Daily Beast presented a slideshow of celebrities pictured with their dimpled-cheeked children and shared the age at which their bundle of joys were conceived and delivered.
Results were plotted on a graph of 'bundle cost' against 'bundle effectiveness', and the maximum cost at which the bundle remained cost-effective was identified for each level of effectiveness.
The minimum level of effectiveness at which the bundle would remain cost-effective assuming negligible implementation costs ($1) is given in Table 3.
Table 3 also shows the maximum cost for at which the bundle would remain cost-effective assuming it would be able to effectively eliminate infection (RR CR-BSI = 0.001).
If decision makers place no value on the extra capacity released by infection control (valuing released bed-days at only the variable costs saved) then the cost threshold at which the bundle is cost-effective is halved relative to the baseline analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com