Specifically, we suggested that the bulkier substituents projecting into the HBP1 and HBP2 regions of the TTR∶FLP pocket might significantly improve TTR-inhibitor interactions and reduce its binding affinity for COX-1 and COX-2 due to steric hindrance.
Both molecules contain a bulky group that projects toward ERα M421, which, in turn, must undergo a large conformational change.
Occupants of 380 West 12th Street had first opposed the project as too bulky.
Right-sided colon cancers (RSCCs) are typically bulky, exophytic, polypoid lesions that project into the lumen and cause significant anemia, whereas left-sided colorectal cancers (LSCRCs) are typically infiltrating, constricting lesions that encircle the lumen, often leading to obstruction [ 1].
Unlike the Microsoft Surface, the project needs no special, bulky hardware – unless you a consider a little parrot-like Kinect sensor on your shoulder bulky.
He is vainly trying to deter Jeanne-Claude from emptying the contents of a bulky manila folder labeled "The Gates, Project for Central Park, New York City" onto a coffee table laden with books about their monumental art projects.
The bulky side chain of the V157 residue projects itself over such kink in a more efficient way than the analogous A157 from ER.
She posted a video of her in the bulky, garishly colored shoes to YouTube and within days the project went viral.
The WD signature tryptophan (or phenylalanine/tyrosine replacement) projects from the face of each propeller blade to pack against a bulky residue (frequently leucine) located at the end of the D-strand and projecting from the rear of the preceding blade.
On the other hand, he's a supporter of the Metrotech project: it's out of scale, introducing too-high, too-bulky buildings into a medium-density area and, worse, a sports stadium.
