Its relatively bulky lipophilic portion might allow it for better drug solubilization.
The bulky, aromatic portion of compound 2 occupied the hDAAO subpocket and stabilized an opening of the active-site lid.
Our reasoning was that this fusion protein could lose its ability to generate the RecA filament formation because of the bulky GFP portion.
The bulky hydrophobic portions of gallate derivatives were considered to interact with tyrosinase's hydrophobic protein bulk surrounding the binuclear copper active site and thus gallate derivatives exerted the anti-tyrosinase effect (Tanford [1980]).
A common pitfall is the presence of a bulky exophytic tumour arising from the vaginal portion of the cervix.
But China's ascendancy is in manufactured goods, from shoes and furniture to fax machines and electric fans, and these tend to be bulky products for which shipping and logistics account for a considerable portion of the final price.
The Cottonogenic diol derivatives are constrained into a chiral, gauche arrangement with the bulkier substituents adopt a pseudo-equatorial position pointing away from the remaining portion of the complex.
Slimmed down from the bulky statesman of yore - a transformation he puts down to "no butter, small portions, and a healthy amount of whisky" - these days he cuts a strangely impish figure, an impression only underlined by the fact that, once he's warmed up, a punchline and mischievous grin are never far away.
Sales of LCD TVs in particular are expected to account for an ever larger portion of the market (see chart) as consumers embrace these new technologies at the expense of bulky models based on old-fashioned cathode-ray tubes (CRTs).
This active-site area, also termed a 'subpocket' [ 30], is known to associate with the bulky side chains of DAAO substrates such as D-tryptophan [ 28] and is occupied by portions of some DAAO inhibitors [ 13, 30].
