However, some common characteristics of dipeptide uptake can be extracted from the experiments: except for the rather bulky compound AC-CA, all other l-alanine (A) containing dipeptides were taken up very fast.
We have selected compound 7, as the most potent and bulky compound, to assess the ability of a small molecule to inhibit the interaction of CDC25B with the CDK2/Cyclin A substrate.
Originally, they were found to degrade anthraquinone derivatives, such as Reactive Blue 5, a synthetic dye, as well as relatively bulky compounds used in the textile industry [ 18].
Due to the larger binding pocket of BChE, bulkier compounds like DHT derivatives are easily placed themselves inside the binding gorge.
Based on the TTR∶FLP complex crystal structure, we have hypothesized that the bulkier compounds may bind specifically to TTR without inhibiting COX-1, characterized by comparatively smaller hydrophobic binding pockets [22].
At structural level, the catalytic triad of E. coli BioH [PDB: 1M33] is buried between two domains and was not readily accessible for bulkier compounds [ 12].
In the present study, we also observed a similar trend for TCBPA and TBBPA, which was consistent with a previous study suggesting that bulkier compounds bind more strongly with PPARγ (Riu et al. 2011).
No structural data are available for Sirtuin complexes with any of these compounds, but our structure comparison (see above) suggests that smaller scaffolds might enable these compounds to exploit the site where 3 was docked, which appears not to be accessible for bulkier compounds in Sirt3, 5, and 6.
Rational approaches to successful lipase-catalyzed kinetic resolutions of very bulky chiral compounds are briefly reviewed: substrate design and high-temperature biocatalysis.
We investigated the effects of mesopore generation in a MFI zeolite when used as a catalyst in liquid-phase Friedel Crafts acylation reactions of bulky aromatic compounds.
It was found that zeolites with channel intersection cavities of comparable size to their apertures, like zeolite beta, were minimally affected by coke formation; thus the size of the channel intersection should be only slightly larger than that of the zeolite aperture, such that the coke precursors are unable to remain trapped inside the cavities and form bulky carbonaceous compounds.
