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In humans, the bulk of systemic magnesium uptake occurs via the small intestine and is mediated by the action of the TRPM6 (and probably TRPM7) cation channels (reviewed in [1], [2]).
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But more importantly, since the periphery of the eurozone bore the bulk of the systemic risks inherent to the common currency area, while the benefits were shared by both the core and the periphery, it's deeply unfair that the burden of solving the crisis has been placed so overwhelmingly on the periphery countries through the debilitating austerity measures demanded by the core countries.
Therefore, it is possible that the bulk of the systemic proinflammatory cytokines in the obese, insulin resistant state are derived from non-adipose cellular and tissue sources.
Surgery is the primary treatment recommendation for cancer stages I III. 2 For those with metastatic disease, cytoreductive nephrectomy may be part of a combined modality approach to decrease tumor bulk prior to administration of systemic therapy.
Although there are some data from longer term studies, the bulk of the evidence supporting the lack of systemic effects with ciclesonide therapy is limited to 12 weeks of treatment.
The bulk of the timeline for those early, long-lasting consent decrees also came during the George W. Bush administration, which, like the Trump administration, wasn't particularly friendly to the sort of systemic reviews undertaken during the Obama years.
Neurologic Complications of Systemic Anticancer Therapy.
Second are questions of systemic risk.
A survey of systemic risk analytics.
We deal with a lot of systemic racism.
There was no evidence of systemic failure in the police.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com