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Current treatments of cancer have shown efficacy in removing the bulk of differentiated cancer cells while failing to eliminate the cancer stem cells responsible for tumor relapse.
Current treatments of cancer have shown efficacy in removing the bulk of differentiated cancer cells while failing to eliminate the cancer stem cells responsible for tumour relapse.
Above observations support metformin as an attractive agent for chemoprevention and use of low-dose for long period in combination with cytotoxic agents like DOX to kill both CSCs and the bulk of differentiated cancer cells.
Secondly, there is also a possibility that mifepristone blocks the growth of scarce tumor initiating cells with the capacity to regenerate the culture and that may remain in culture because are resistant to cisplatin-paclitaxel in contrast to the bulk of differentiated cancer cells that succumb to the chemotherapy [ 65].
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In addition, PSA-/low PC cells were also more resistant to androgen-deprivation therapy and chemotherapy, including paclitaxel, than the bulk mass of differentiated PSA+ PC cells in vitro and in vivo (Qin et al, 2012).
These cells appear to be capable of asymmetric division and self-renewal, and are only a minor fraction among the bulk of more differentiated cells in the tumor [16], [17], [18].
Our results corroborate those found by Wurmbach et al.[ 18], who categorized the bulk of the differentiated genes as participating in immune response.
In contrast, in the bulk of more differentiated non-neurosphere GBM cells and in GBM surgical specimens, NEU4 expression is very low.
They appear to be capable of asymmetric division and self renewal, are only a minor faction among the bulk of more differentiated cells in the tumor, and can reconstitute all the cell types in the tumor of origin.
T-ICs comprise only a minor fraction among the bulk of the more differentiated cells in the tumor.
The bulk of the tumor consists of differentiated non-CSCs destined for final death and unable to recreate a tumor de novo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com