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The proportion of cell volume that is cytosol varies: for example while this compartment forms the bulk of cell structure in bacteria, in plant cells the main compartment is the large central vacuole.
Intriguingly, this compound was more effective, in our hands, on this subpopulation enriched in self-renewing cells than on the bulk of cell lines.
Whereas carbohydrates and lignin constitute the bulk of cell wall materials, structural proteins also form a network that contributes to the architecture and functionality of the cell wall.
In fact, a large fraction of long-lived cellular proteins, the bulk of cell constituents, are degraded by this process (29).
Among the tamoxifen-resistant cell lines, unsupervised hierarchical clustering revealed very similar expression profiles (Supplementary Figure S1, 15 376 genes) and did not group the bulk of cell lines belonging to a particular cVIS (Van Agthoven et al, 2009b).
In particular, in the CSC model only a small proportion of tumor cells are proposed to be able to proliferate and self-renew extensively, thus sustaining tumor growth, while the bulk of cell populations proceed to differentiate into heterogeneous clones that become the phenotypic signature of the tumor [ 1].
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analyze and mine biomarkers mainly based on the bulk of cells or tissue samples.
Reasoning that the selected T cells, to be effective, would have to make up the bulk of cells in each patient's immune system, the team administered chemotherapy to the patients to temporarily wipe out substantial numbers of existing immune cells.
Ovarian cancers are composed of tumor-driving E/M-MP cells as well as non-tumorigenic differentiated cancer cells that compose the bulk of cells in a tumor.
Single cells were isolated by suspending a bulk of cells in PBS until a dilution of about 1 cell/0.5 µl was obtained.
On day 12 the bulk of cells we sorted into CD4+CD25lo and CD4+CD25hi populations and processed as previously described (online supplemental material Figure S3B).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com