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Compared to bulk level RNA-seq, scRNA-seq has at least two advantages.
At a bulk level, flowability improvement of an API through crystal habit manipulation is exemplified.
Nanostructured materials exhibit peculiar and unique properties unseen at the bulk level.
Molecular simulation offers an unprecedented molecular-level resolution with an ability to reproduce molecular and bulk level properties.
This is because bulk level analysis can only describe the general trends in a population that can mask cellular subtypes [99].
A systematic assessment of key material attributes of active pharmaceutical ingredients (APIs) using minimal material approach is illustrated at the particulate level and bulk level.
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When added at higher bulk levels, Si displaced (beneficial) Th from the boundaries.
However, these techniques contained numerous approximations to allow scaling up the properties from nanoscale to bulk levels.
For the first set, ZrC films without Si exhibited high porosity and low hardness, but with 31.5% SiC, the films were at the bulk levels for ZrC and the porosity was significantly reduced.
Full physical characterisation of solid materials is now made possible with the help of high-resolution analytical techniques (infrared spectroscopy, powder X-ray diffraction, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)) on the molecular, particulate and bulk levels (Pifferi et al. 1999).
Moreover, bulk levels of hippocampal H3K4me3 were found to increase in response to fear conditioning training (Gupta et al, 2010).
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