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In addition, the one-tailed bulk design was less powerful than the two-tailed bulk design at comparable population size, sequencing depth, and heritability.
Two experimental designs were simulated: high vs. control bulks (one-tailed bulk design) and high vs. low bulks (two-tailed bulk design).
For example, 5000× sequencing depth is sufficient for 99% chance of detecting a 5%-effect QTL with a two-tailed bulk design, but has the detection power of just 90% with one-tailed bulk design.
Bulk design of primer sets to SNPs or other genome targets can be performed using the Primer3 executable [ 10].
We used the high vs. control bulk design and the beneficial allele in the high bulk was set to 0.6.
In such a case, besides the phenotypic data also the marker data spanning the different QTL regions is taken into account during the bulk design.
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Initial device results show that tri-gate bulk MOSFET design is beneficial for reduced variability.
As compared with the bulk FinFET design, the tri-gate bulk MOSFET offers comparable performance and variability.
A tri-gate bulk MOSFET design combining retrograde channel doping with a multi-gate structure is proposed to provide an evolutionary pathway for bulk CMOS scaling.
Finally, a new bulk carrier design is taken as a case study to prove the validity and necessity of this expert system.
In contrast to conventional bulk device design, this work shows that the wire diameter does not necessarily follow the common stringent scaling rule.
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