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Functional complexity of the human body, with over 200 specialized cell types, and intricately built tissues and organs, arises from a single set of instructions: the human genome.
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Researchers at Wake Forest University have successfully built tissue-engineered bladders and transplanted them into patients with spina bifida.
Many natural history museums have built tissue collections and made digital information (e.g., photographs, publications, geographic coordinates) freely available on the Internet.
Bottom-up technology, fabricating from small molecules a complete tissue, is attractive because the built tissue can be functional and suitable as in vitro models that can more closely model diseases.
This advance will help engineers build tissues that have desirable structures.
During embryogenesis, this mechanism is fundamental to build tissues and organs because it generates cell diversity.
Some encode enzymes that convert elemental nitrogen from the air to ammonia, which organisms can use to build tissues.
Attempts to build tissues or organs in vitro have utilized both scaffold and scaffold-free approaches.
Nelson and her colleagues build tissues in culture using microfabrication techniques similar to those used in the semiconductor industry.
Currently, her lab is using the fruit fly as a model organism to investigate how cells build tissues during embryo development.
An understanding of the cell rearrangements that occur during normal embryonic development will uncover general principles that build tissues and organs and can provide insight into how deranged versions of these processes contribute to human disease.
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