In particular for the easier targets with many alternative templates with a high degree of sequence identity, quality is readily improved with a few percentages over the highest ranked model built on a single template.
Cilia are highly conserved microtubule-based organelles that project from the cell surface and are built on a basal body template derived from the centrosome.
To complete the examination of the conformational preferences of the studied compounds, molecular docking of azinesulfonamides was performed with the use of recently developed 5-HT7 and 5-HT1A homodels models, built on a dopaminergic D3 receptor template (PDB ID: 3PBL) [13, 26 31].
Yet audiences seem to like shows built on a perpetual quest for a relative's killer, a template that goes back to "The Fugitive".
In this work, we present CHOPIN, a database built on an automated, high-throughput modelling pipeline using multiple templates, annotated according to functional state.
It is now virtually impossible to surf the cable spectrum without landing on a series built on the Beers template: shows about bush pilots, swamp loggers, wild-pig hunters, gold miners, snake wranglers, repo men, tugboat operators, animal-control officers.
A triumvirate of gangster pictures were released in the early 1930s—Little Caesar (1931), The Public Enemy (1931), and Scarface (1932)—which were built on the template created by the first gangster movie, 1927's Underworld.
MCC values obtained for various numbers of models included in the SIFt profile for models built on various templates for a) actives/true inactives, b) actives/DUDs, and c) actives/ZINC discrimination.
