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The structure was solved using the SAD approach with the data collected from the crystal soaked in iodide, and the AutoSol wizard as implemented in PHENIX (Adams et al., 2010), which also built an initial model.
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This yielded a readily interpretable electron density map which was used to build an initial model of the protein with program O [37].
Following density modification with DM [19], Arp/Warp [20] was used to build an initial model with ∼150 of 253 residues automatically positioned.
Next, we use K-medoids clustering to build an initial model Θ0.
Phenix.autobuild was used to build an initial model of DC-LAMP but succeeded only in building parts of one of the two molecules in the asymmetric unit.
Three structurally conserved regions (SCRs) were used to build an initial model of CcBV cystatin 1, with three deletions and no insertion relative to the template.
We first built an initial draft model iAbaylyiv1 using information from the genome annotation, metabolic pathways databases, and the literature.
The remaining four studies were Markov model-based economic evaluations, all built on an initial model developed by Oostenbrink et al[ 12].
Tabb notes that when a company signs up to Looker, the company currently helps build out an initial model that fits your own business, using the LookML language.
"Companies that can build an initial knowledge model and launch an initial intelligent service or product, then use this first product to capture new data and improve the knowledge model on a continuing basis, will quickly create clear class-leading products and services that competitors will struggle to keep up with".
The data from this experiment was used to build an initial Kriging model of the concentration and pH dependence of PYK activity.
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