PSI-BLAST builds a position-specific scoring matrix, or PSSM, iteratively, by running BLAST searches for a query against a database.
At first, Dr. Gilman's reports on the trial's progress were positive, and SAC built a position in the two drug makers worth approximately $700 million, according to prosecutors.
Sony has been seeking to build a position in the entertainment software business for some time.
The fund also has built a position in Masco, which sells home improvement items like cabinets and plumbing fixtures.
Now larger companies are pursuing smaller companies to build a position in a particular market and to fill certain niches.
After the weed discovery, which occurred in 2010, Monsanto began spending heavily to build a position in RNA technology.
"He had to build a position against me to establish his own position, so he has been speaking against the specificity of Latin American art," she said.
It praised Groupon for its "prime mover status and scale," but warned investors to "wait for a better entry point to build a position".
The JPMorgan investigation centers on whether the bank's traders in London built a position so big that they manipulated the market for financial contracts known as derivatives.
By last May, the mutual fund had built a position of about $150 million in coverage, which it doubled over the summer.
Of course, Mr. Buffett and other big-time investors could avoid the secrecy by accumulating their holdings within the three-month period between S.E.C. filings, but Mr. Buffett said sometimes more time was needed to build a position.
