In this extended example, we combine nonlocal assignment, lists, and dictionaries to build a constraint-based system that supports computation in multiple directions.
The level of detail necessary to build a constraint-based model of a bacterium's metabolism is relatively low; the only information required is the precise reaction stoichiometries and directions, in order to account for mass balance and irreversibility constraints.
In an effort to enable the analysis of P. putida KT2440 from a systems biology perspective and to foster the development of its biotechnological applications, we built a constraint-based metabolic reconstruction (iJP815) of this strain [ 8, 9].
The new scheme is integrated in a conflict-analysis algorithm reminiscent of a modern systematic propositional satisfiability (SAT) solver: it traverses the conflict graph backwards and gradually builds an asserting conflict constraint.
Interestingly, for PG it is possible to build a network up in constraint density through a bootstrapping method by first placing a certain number of constraints at random, and then adding more constraints.
We used the power of 11,257 whole-genome sequences and 16,384 heptamers (7-nt motifs) to build a map of sequence constraint for the human species.
We have also built a library of parametric, constraint-based, manufacturable solid patterns that occur frequently in filigree jewelry.
As is the case for other CAD/CAE integrated systems (e.g., IsoGeometric Analysis (IGA)), the designer is only required to build a CAD model, define constraints and adjust designs.
In addition, federal regulators are moving to create a more open national wireless network when it auctions off spectrum licenses in January that would allow bidders to build a network free from carrier constraint.
Therefore, the only constraint to build a similar type of sensor is to find a region of the aptamer that could be replaced by or incorporated with an antisense element.
