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During metabolic stress, autophagy is essential to maintain cellular metabolism and homeostasis by clearing toxic wastes and recycling building blocks for biosynthesis.
The activity of eukaryotic PFK is modulated by a number of effectors in response to the cell's needs for energy and building blocks for biosynthesis.
Increased glycolysis most likely contributes building blocks for biosynthesis.
Firstly, a wide array of tumor cells have been shown to be able to use not only glucose, but also glutamine for generating cellular energy, reducing power, and metabolic building blocks for biosynthesis.
Through the catabolic metabolism, autophagy digests cellular contents to provide cellular energy and building blocks for biosynthesis.
Engineering the pathway-specific building blocks for biosynthesis occasionally improves production of some polyketide or nonribosomal peptide natural products.
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Branched short-chain acyl-CoAs (e.g. isobutyryl-CoA, isovaleryl-CoA and 2-methylbutyryl-CoA), derived from the degradation of branched-chain amino acids (BCAAs), are essential building blocks for the biosynthesis of bitter acids in hops.
DOI: http://dx.doi.org/10.7554/eLife.07141.002 Deoxyribonucleotides, the building blocks for DNA biosynthesis, are produced in the cell from ribonucleotide precursors by ribonucleotide reductase (RNR).
The data also suggest that MeJA responsiveness of the MEP and MEV pathways provide 5C building blocks for the biosynthesis of the diverse terpene metabolites.
Therefore, it is reasonable to hypothesize that the downstream region of the scytonemin cluster is likely dedicated to supplying the building blocks for the biosynthesis of scytonemin, while the standard housekeeping copies remain important for central metabolism.
Central to cell growth is the metabolism of nutrients to generate energy, create building blocks for macromolecular biosynthesis, and promote synthesis of the panoply of molecules needed to make two cells from one.
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