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These experimental data guided us to build a structural model, using the Kv1.2 crystal structure as a template [13].
The NMR structure of a functionally active hIL-3 variant SC-65369 (PDB accession number 1JLI) was also taken from the Protein Data Bank to build a structural model for the wild type hIL-3 (14–125).
We carried out a Φ-value analysis of the folding reaction of the Tho1 SAP domain in order to build a structural model of the transition state.
Both programs identified the human FGF9 structure [PDB 1IHK] as the best candidate (most similar; E-value = 10-45) to build a structural model of FGF5.
Having the structures of both the crN-dimer and the crCC-dimer of Bld12p allowed us to build a structural model of higher-order oligomers using both dimer interfaces.
This analysis allowed us to build a structural model of the HSP90 SGT1 complex and to obtain a compensatory mutant pair between both partners that is able to restore virus resistance in vivo through Rx (Resistance to potato virus X) immune sensor stabilization.
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To elucidate the possible role of S174 phosphorylation, we built a structural model of Saccharomyces cerevisiae Atg31 using a homologous modeling method and a threading modeling method (Pronk et al., 2013).
To overcome these challenges, we built a structural model of the PVX particle based on the available structures from pepino mosaic virus (PepMV), a close cousin of PVX.
I have built a structural model of the chemokine receptor CCR5 and used it to explain the binding and selectivity of the antagonist TAK779.
We have also built a structural model based on the results of the above morphological characterizations in order to discuss the potential in vivo performance and functionality of each type of prosthesis.
To build a structure model for a target protein sequence, the TBM process consists of four major steps: identification of structural templates, alignment of target sequence to structural templates (or sequence-structure alignment), model building, and model quality evaluation.
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build a structural component
build a parsimonious model
build a multivariate model
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build a structure model
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