To build an independent benchmark set, we thoroughly mined database annotations and scientific reports to collate 29 protein chains, which have been investigated using biophysical techniques and have been shown to be disordered in isolation and to fold upon protein binding.
To build a high quality benchmark dataset, the entries with hydroxylation annotation confidence - "probable", "potential", or "by similarity" were excluded.
However, we were unable to collect sufficient problematic sequences in which secondary structure awareness would clearly improve alignment accuracy to build a dataset for benchmarking.
We have thus built a complete benchmarking system for this problem, which we use to compare our methods.
Then you would either buy a mutual fund, like the Vanguard Balanced Index fund, designed to match the benchmark, or build a portfolio on your own that mimicked it.
Then, rather than rely on arbitrarily selected case-dependent measurement locations as in the NUMISHEET benchmark problems, we build a reduced order "shape space" where this level set evolves, by extending our recent shape manifold approach to the problem of springback assessment for 3D shapes.
"We will compete both on technology and price, and build a bike that will set new benchmarks and win an appropriate market share".
Microsoft's Type Cover for the Surface still sets the benchmark for how to build a cover with a good keyboard.
"But we want to build a world class system for our athletes and coaches that can be benchmarked against best practice anywhere across the globe".
My partners at Benchmark and I believe that Silicon Valley is still the best place to build a technology startup.
