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For instance, in oral cancer, you get this white leucoplakia thing before you get the cancer - you look in that and find the p53 is buggered, you know it's on the way to being a cancer cell.
PSI be buggered, you're not going to make it through those long puncturing canines (shouldn't that be felines?) nor the slashings and tearings of that wild pendulum of a head.
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"You bugger, you left that in!" she says.
It means "I will bugger you and stuff your gobs".
In one famous case, academics found it unseemly to deal with an insult in the Roman author Catullus's Carmen 16, roughly rendered "I will bugger you and I will fuck your mouths, / Aurelius, you pathic, and you queer, Furius".
If a Banshee is buggering you, shoot at the two feet hanging out the back as the pilot turns to get another shot at you.
He turned my sister's dictum - you're not entitled to an opinion, you're entitled to bugger all, you – to ashes.
"You'll just have to wait," she said, "if you want to see it, and if you truly do you'll wait, and if you truly don't you can bugger off and you can miss it, and I can see it all to myself".
"I'm a lucky bugger, you know," he says.
I said, "Bugger you, then".' And she threw back her head and gave another filthy laugh.
Once you've gone through your first "dry", you're never quite the same cocky bugger you were before, however much you try to laugh it off.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com