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In contrast, trait-based protective factors (e.g., pride) should buffer the deleterious effects of risk factors.
Chaperones are also highly expressed and may buffer the deleterious effects of the large number of non-synonymous mutations observed in essential T. hominis genes.
For example, disordered regions could buffer the deleterious effects of mutations introduced by low-fidelity virus polymerases better than would structured domains.
It is also known that the experience of positive emotions can buffer the deleterious effects of stress in civilian populations [ 32, 33].
Although Hdac5 expression was unaffected, there was significant up-regulation of Hdac9 in both strains of HDAC4 cKOs (Fig. 1 E, F ), which may help to buffer the deleterious effects of HDAC4 knockout in these mice.
The acquisition of a protein-protein interaction between the mating factor MAT α2 and Mcm1 was able to buffer the deleterious effects of mutations that strengthened Mcm1 binding sites [ 7].
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Our data suggest that imbalance of visceral and subcutaneous fat distribution, i.e. increased visceral fat with decreased subcutaneous fat accumulation, is an important determinant of atherosclerosis, whereas increased subcutaneous fat accumulation could buffer the deleterious effect of visceral fat accumulation in patients with type 2 diabetes.
This wide historical refugium may have buffered the deleterious effect of demographical retraction on genetic diversity due to the long-term population persistence and connectivity, maintaining a relatively high level of genetic diversity and allelic richness in most populations with significant but low genetic differentiation among them.
Interestingly, Lp WJL association, which enhances peptidase expression and activity, buffers the deleterious effect of protease inhibitors on juvenile growth, as exemplified by a reduced sensitivity to protease inhibitors of Lp WJL -associated larvae, yet at higher protease inhibitors concentration, Lp WJL -mediated growth promotion was also diminished.
By its nature, our method could select compensatory pathway pairs that buffer the deleterious effect of the failure of either one, without the need of physical interaction data.
Importantly, Bergman et al. use a cross-sectional study design, with 1,200 subjects in their 6 11th decades of life to show experimental support for the buffering hypothesis; their data support the idea that CETP VV genotype buffers the deleterious effects of an LPA genotype.
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