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These structural changes could contribute to the decreased folding yield in the DMSO/detergent buffer, by destabilizing a late folding intermediate, which shifts the equilibrium towards the non-native conformation (Leta Aboye et al. 2008).
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Additionally, we found that Leo1 acted by destabilizing nucleosomes in a general manner and thereby modulating chromatin states.
Mechanistically, SIRT3 mediates metabolic reprogramming by destabilizing HIF-1 α, a transcription factor that controls glycolytic gene expression.
"The insurgents are trying to find a toehold there by destabilizing it to show their presence all over the country".
Point mutations have been shown to promote protein aggregation by destabilizing the native, globular state of a protein [52].
If the "smoothing effect" prevails, added damping may act in an unintuitive way by destabilizing the system.
To account for this, a model is developed wherein Na+, which destabilizes secondary and tertiary structures in the presence of Mg2+, facilitates native folding by destabilizing the multiple alternative secondary structures with a higher-order dependence.
Our findings suggest that NO and its congeners can induce apoptosis by destabilizing mitochondria via deenergization and/or by inducing a specific Ca2+ release followed by Ca2+ cycling.
Downregulation of parvalbumin and calbindin could therefore lead to a loss of compensation, by destabilizing supralinear calcium release and disrupting any homeostasis achieved by downregulation of other molecules.
Gentrification, by definition, destabilizes a neighborhood.
He said South Ossetia served a useful purpose for Russia, by destabilizing the Georgian economy and Mr. Saakashvili's government.
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CEO of Professional Science Editing for Scientists @ prosciediting.com