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Buccal formulation has previously been designed as an alternative form of dosing verapamil.
However, for norverapamil the corresponding values for buccal formulation were much lower than for a conventional tablet.
For buccal formulation the average values of Cmax and AUC0 24 h for verapamil were much higher than for the reference Staveran tablets and amounted to 51.28 and 320.23 ng/ml h, respectively.
Better parameters of bioavailability of verapamil from buccal formulation of twice a smaller dose than that in the tablet, prove that this new drug might be form more effective clinically than the conventional one.
2 Another buccal formulation is fentanyl buccal tablet (FBT), which has been approved in United States and Europe.
Oral transmucosal fentanyl citrate (OTFC) (United States and Europe: Actiq®; Cephalon, Inc., Frazer, PA) is a buccal formulation composed of a fentanyl lozenge on a stick.
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Interesting example is development of transdermal and buccal formulations of testosterone.
In FTIR spectrometer (Frontier PerkinElmer, Waltham, MA, USA), 10 mg of RB and freeze-dried buccal film formulation with and without RB were used to investigate possible chemical interactions between RB and other components of film formulation.
Pharmacokinetics of verapamil and its metabolite norverapamil, from buccal drug formulation administered in a dose 20 mg in relation to conventional tablets of verapamil 40 mg, used in medical practice, was determined.
Figure 5b shows spectra for components of buccal film formulation (a film without RB).
DSC thermograms of RB, buccal film formulation components with and without RB are shown in Fig. 6.
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