This observation brought to the hypothesis that the contribution of TrkA overexpression (acquired through genomic gain) to the initial progression of the primary tumor might be negatively selected afterwards (by down-regulating gene expression), as it is reflected in our cell lines derived from advanced MMs.
These models tend to bring the hypotheses into sharper focus, which leads to their revision, which leads to new models, and so on, in a continual process of iteration.
They brought a hypothesis driven quantitative approach to investing.
This observation has brought forward the hypothesis that a unique and defined expression site for var gene transcription could exist in P. falciparum.
The absence of loss of allelic diversity could be due to immigration in post-epidemic population [96] but the detection of first generation migrant analysis brought no evidence for this hypothesis.
I would like to see this section elaborated upon, as the idea raises a lot of interesting questions and there may perhaps be data lurking in the literature that can be brought to bear on this hypothesis.
Theoretical models and increasingly sophisticated data from hunter-gatherer populations have been brought to bear on this hypothesis, and the related idea that surviving grandmothers increase their grandchildren's reproductive success (and thus, their own inclusive fitness) (Rogers 1993; Hawkes 2004; Shanley et al. 2007).
Perspectives brought by complementation/supplementation hypothesis to conservation plans in dynamic farmland mosaics are discussed.
Unfortunately, data that brought the amyloid hypothesis to its current, Aβ oligomer-based state, including the aspects concerning synaptotoxicity, arose from material driven by such low-resolution techniques.
Therefore, these observations have logically brought about the hypothesis that radiation exposure from internal I causes DNA double-strand breaks, resulting in oncogenic genome rearrangements after illegitimate recombination.
