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Deletion of an in-frame initiation codon found upstream of the main translation initiation site of RNA-2 brought about a substantial increase in foreign protein production.
The results showed that Stat3 inhibition by CPA7 treatment, or downregulation through shRNA expression brought about a substantial reduction in Cx43 mRNA levels, indicating an effect of Stat3 upon Cx43 gene transcription as well.
As expected, acclimation of WT leaves to high light (1000 μmol m-2 s-1) brought about a substantial decrease in the PSII antenna system (monomeric Lhcb and trimeric LHCII; B2 and B3 bands in Fig. 10A, respectively) relative to the PSII reaction center (B5 band).
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This was similar to the results reported in the earlier Phase III study, and suggested that dalfampridine SR may bring about a clinically significant improvement in walking speed and strength in a substantial portion of the MS patient population.
What they have not done is make any substantial progress toward enacting a package of tax cuts and new spending that might help bring about a faster recovery.
Their purpose is to bring about a desired result.
"Every police officer should get a merit pay increase because every police officer did work that helped bring about a substantial reduction in crime".
What this all adds up to is the likely election of a number of high profile city mayors within the next year that will bring about a substantial shift in English politics.
We argue that a technology choice is significant in actual policies if this difference brings about a substantial change to resource price, extraction, and exploration schedules.
Improving birth weight could thus potentially bring about a substantial potential benefit given the associations between high blood pressure and various health conditions such as hypertension and stroke.
In a similar manner, these circumstances stirred the dynamic of a distribution of duties between the public and private sectors among the Southern European countries under analysis thus bringing about a substantial change in port governance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com