Sentence examples for broadly suppress from inspiring English sources

CO was found to broadly suppress LPS-induced immediate-early genes that initiate and propagate inflammation including pivotal transcription factors (e.g. EGR family members and ATF3), cytokines (e.g. IL-1β and TNF-α) and chemokines (CCL5, CXCL1 and IL-8).

The current standard of therapy for autoimmune diseases seeks to broadly suppress the immune system, necessitating either the physical deletion or inactivation of entire subsets of T cells.

With respect to breast cancer, Notch-dependent upregulation of survivin [ 35] may broadly suppress apoptosis, deregulate cell cycle progression [ 21], and ultimately promote resistance to mainstay therapeutic agents in this disease, such as taxanes [ 47] and DNA damaging agents [ 48].

Consequently, the effective relative motion between the overriding plate and the subducting plate around the locked area was broadly suppressed compared with other regions, thereby reducing the cumulative seismic slip of M7 8-class earthquakes.

The drugs aim to short-circuit the abnormal antibody activity that drives the disease, without broadly suppressing the immune system the way existing treatments (such as oral steroids) do.

Through site-specific dephosphorylation, constitutively active PP2Ac disrupts the signal-promoting TLR4-MyD88 complex and broadly suppresses the activities of multiple proinflammatory/proapoptotic pathways as well, shifting proinflammatory MyD88 signaling to a prosurvival mode.

Entry of teachers into the transfer markets is broadly suppressed, but the overall impact on improving teacher quality at poor schools is minimal, as the largest change in the distribution of teachers is a reduction in the number of newly minted teachers and an increase in the number of low experience teacher.

The Sir2/SIRT1 family of NAD+-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a diet that broadly suppresses cancer in mammals.

CO broadly suppresses the initial inflammatory response of human monocytes to LPS by reshaping proximal events in TLR4 signal transduction such as stress kinase responses and early NF-κB activation.

We can hypothesize that inhibition of Porcn could be the most effective strategy for broadly suppressing Wnt signaling.

S mansoni antigen-specific antibody levels and praziquantel-induced boosts in antibody levels were broadly suppressed during pregnancy, but this was not associated with major reduction in the efficacy of praziquantel.