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Tetherin is constitutively expressed in terminally differentiated B cells, bone marrow stromal cells, and plasmacytoid dendritic cells, and is also broadly induced by treatment with IFN-α in various cell types [5], [6].
notch3 is broadly induced in nrg1-3 z26 interneuromast cells.
COX-2 was broadly induced by LPS (TLR4) but more locally by poly(I C) (TLR3).
SPI-2 genes are broadly induced to evade immune responses by host cells.
CR broadly induced the expression of genes known to inhibit oxidative stress (e.g., Mt1, Mt2), inflammation (e.g., Nfkbia, Timp3) and tumorigenesis (e.g., Txnip, Zbtb16).
More broadly, induced progenitor cells have been shown to regenerate different organs and systems in neurodegenerative [5], cardiovascular [6,7] and musculoskeletal [8] disorders.
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DOI: http://dx.doi.org/10.7554/eLife.00459.016 Heat stress broadly induces protein misfolding and denaturation across all cellular compartments.
These new "headless" hemagglutinin constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and induce broadly protective/heterosubtypic immunity in animal models, bringing us a step closer to "universal" influenza virus vaccines.
Many vaccine candidates tested to date produce these conventional Abs, but none have yet induced broadly reactive neutralizing antibodies (bnAbs).
In the wild-type embryos, Fgf8 is induced broadly in the rhombomere 1 but gets restricted to the most anterior rhombomere 1 next to the Wnt expressing posterior midbrain by E9.0.
In this vein, our observation that the pro-exocrine bHLH factor Ptf1a can induce Math6 expression in vitro (Figure 8) supports the notion that this bHLH factor may lie upstream of Math6 in the exocrine cell lineage [37], and suggests a general paradigm in which Math6 is induced broadly by class II bHLH factors that initiate differentiation in different cell lineages.
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