Sentence examples for broadly implicated in from inspiring English sources

Natural antisense transcripts (NATs) have been broadly implicated in regulating gene expression and chromosome structure [29] [34].

Decreased expression of Ppara has also been observed in aging heart, liver, and kidney [72] and recently it has been broadly implicated in aging and systemic inflammation [73].

In addition to effects on eicosanoid metabolism TGM2 also activates the transcription factor NFκB that is broadly implicated in the generation of pro-inflammatory cytokines in asthma and other inflammatory diseases, and induces iNOS via NFκB [42].

The fact that positive correlations between RT and BOLD amplitude were found primarily in frontal regions is consistent with the conventional wisdom that MFC and lateral PFC regions are central components of a cognitive control network broadly implicated in supporting effortful, goal-directed activity [40], [41].

Finally, integrins are broadly implicated in bone metastasis due to their ability to induce mitogenic intracellular signaling.

In summary, disruption of the homeostatic balance between proliferation and apoptosis has been broadly implicated in cancer and silibinin tips the balance away from development of colorectal cancer.

MAP kinases, including ERK, p38, and JNK, have been broadly implicated as regulators of cell proliferation and migration in diverse cell types in response to a variety of stimuli [ 42- 44].

The differentially expressed genes also broadly implicated receptor-like kinases, which were down-regulated in the resistant lines, and other growth and defense genes, which were up-regulated in resistant lines.

These data are in agreement with previous studies that broadly implicate the BMP family in cancer, and specifically implicate RLF in SCLC.

However, when asked about specific personnel, such as the nurses, the participant's employer in prison or prison education officers, many inmates were more reflective and considered staff as individuals rather than broadly implicating all staff within the correctional system as not being trustworthy.

These observations broadly implicate plasma membrane potassium, sodium, and calcium transport as important to activity.