Neumann et al. [4] differentiate broadly between an execution environment, a technical domain environment, and a business domain environment.
The use of a fold-change cutoff was justified by the observation that more specific expression patterns had higher fold changes in this experimental context, helping to differentiate between broadly expressed genes and those with ovule-specific expression.
Furthermore, most direct and indirect cost studies conducted in sub-Saharan Africa examine mental disorders broadly, with few studies differentiating the costs due to particular conditions and none specifically examining costs of neurological and substance use disorders.
We note that since the HUI3 differentiates patients more broadly within the middle quartiles, it may be a better method for scoring the HUI in the ACCORD population.
Our results provide a single-cell perspective on epigenomic cell-state dynamics in pluripotent and differentiating cells, and a broadly applicable method for studying DNA methylation both in single cells (scWGBS) and in very small cell populations (μWGBS).
Naïve CD4+ T cells can differentiate into at least four broadly classified functional subgroups.
We have technologies in our portfolio that we have not broadly licensed because we reserved them for differentiating our products.
In a shareholder letter, Joey Levin, IAC CEO and Interim Vimeo CEO, detailed Vimeo's plans to more broadly compete in this space, while also differentiating its service from existing subscription players.
Rapid genome sequencing, transcriptomics of small populations of differentiating cells, powerful bioinformatics, and broadly applicable genome-editing methods can now convert nearly any species inhabiting Darwin's "tangled bank" (Darwin 1959, p. 482) into a "model organism".
Given that Brg1 positively regulates PRC2 repression of Hox loci in undifferentiated ESCs (Ho et al., 2011), we hypothesized that Brg1 is broadly required for PRC2-mediated silencing in differentiating mesoderm.
