Furthermore, in well-worked sediments, MnO2 and FeOOH contents are broadly dependent on particle surface area.[40] Consequently, the finer bank sediments can be expected to contain more reactive Fe and Mn, and hence have an inherently greater poising capacity.
Looking beyond functional beauty or more broadly, dependent beauty accounts of architecture, an inclusivist will seek the thread that ties together architectural objects with aesthetic properties of all description, be they functional, otherwise dependent, or freely (independently) endowed with beauty or other such properties.
Its tissue uptake rate following intravenous injection is variable but broadly dependent on tissue blood flow and cellularity.
Furthermore, the ubiquitous effect of temperature on molecular, metabolic, and developmental processes suggests that these epistatic effects on energy metabolism in ectotherms should be broadly temperature dependent.
Academic interest in modeling CCF, and more broadly in modeling dependent failures, has steadily grown over the years in the number of publications as well as in the sophistication of the analytical tools used.
Nevertheless, the identification of a number of glycan-dependent broadly HIV-neutralizing antibodies from HIV-infected individuals, including 2G12, PG9, PG16, PGT121 123, PGT125 128, and PGT135, strongly suggests that the defensive viral 'glycan shield' can be important targets of vaccines.
Phosphatidylcholine vesicles harboring the lipophilic metal ion carrier A23187 in the bilayer and encapsulating ethylenediamine tetraacetic acid (EDTA) exhibit broadly varied, pH-dependent affinity for Cu2+, Pb2+, Cd2+, and Ca2+ at micromolar levels.
We designed DARTs with a monovalent HIV-1 envelope-binding (Env-binding) arm that was derived from broadly binding, antibody-dependent cellular cytotoxicity-mediating antibodies known to bind to HIV-infected target cells coupled to a monovalent CD3 binding arm designed to engage cytolytic effector T cells (referred to as HIVxCD3 DARTs).
Flavopiridol (Alvocidib, NSC 649890), is a serine/threonine kinase inhibitor that broadly targets cyclin-dependent kinases (CDKs), including the cyclin 9/cyclin T complex (pTEF-b), preventing activation of RNA polymerase II [1] [2].
The broadly acting cyclin-dependent protein kinase (CDK) 7/9 inhibitor roscovitine (RCV) blocks transcription stimulated by CREB in a rat AML cell line and induces death through transcriptional inhibition in human neutrophils.
Given the extensive and intricate networks that, depending on sterol or nutrient availability, post-translationally regulate processing and activation of membrane-bound SREBPs [ 66], our finding that fasting broadly regulates Srebp-dependent pathways already at the transcriptional level is rather surprising.
