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Consistent with their functional conservation, centromeric satellite repeats are broadly conserved in length, in spite of large variation in their DNA sequences[ 51].
Finally, interrogation of stem-cell-derived motor neurons produced from ALS patients harboring a repeat expansion in C9orf72 indicates that at least a subset of these changes are more broadly conserved in ALS.
This tetrad of cysteine residues are that is broadly conserved in the small sub-domain of all the sirtuin family [23].
Maf1 is required for repression of pol III transcription in response to several signal transduction pathways and is broadly conserved in eukaryotes.
In the best-studied case of Salmonella typhimurium, there are more than 40 components involved in various aspects of flagella function, but only about 24 of them are broadly conserved in other motile bacteria and are functionally indispensable [17].
Availability of whole genome tiling array and smRNA datasets for rice [84], [86] allow us to test the hypothesis that transitivity associated with miRNAs (antisense transcription leading to production of siRNAs that flank miRNA target sites or MIRNA loci) is broadly conserved in plants.
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Either cysteine may form a disulfide bridge with a broadly conserved cysteine in EC2.
However, we identified a more broadly conserved motif in Alpha- Beta- and Deltaproteobacteria as well as Cyanobacteria and Firmicutes.
To examine whether confounding properties of conserved 3′-UTR regions might similarly explain the elevated conservation of chimera-supported sites, we compared the z scores for sites bound by broadly conserved miRNAs (miRNAs in families conserved beyond mammals, as listed in TargetScan7) with those bound by less conserved miRNAs.
Target Scan 5.1 revealed 22 miRNAs targeting 12 broadly conserved seed sites in the 3'-UTR of mSIRT1.
Together, we find that the roles of Notch, SoxB and bHLH genes in Nematostella are broadly conserved with their roles in bilaterians; however, the evidence for NvNotch signalling via a canonical Notch mechanism remains ambiguous.
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