Genentech (which created Herceptin) now imagines what it calls "cancer vaccines," tailored not just to broad subtypes of people but to the unique signature of a person's tumor.
The four broad subtypes most likely to be encountered by primary care physicians are acute lymphoblastic, acute myelogenous, chronic lymphocytic, and chronic myelogenous.
Breast cancer cell lines have been classified into three broad subtypes based on the expression of the intrinsic genes: luminal, basal A or basal B [ 29, 30].
Traditionally, somatic sensory neurons have been divided into three broad subtypes: nociceptors (for sensing pain), mechanoreceptors (for sensing touch), and proprioceptors (which sense body position).
We hypothesized that race/ethnic group, sex, age, and/or calendar period variation in adult glioma incidence differs between the two broad subtypes of glioblastoma (GBM) and non-GBM.
Indeed, chromosomal aberrations allow identifying two broad subtypes of disease, one characterized by chromosomal gains (hyperdiploidy) and the other by structural changes (nonhyperdiploidy), leading to different results in terms of prognosis [ 9].
MM is characterized by significant molecular heterogeneity and comprises two broad subtypes of disease that may reflect different underlying oncogenetic pathways of evolution one characterized by chromosomal gains (hyperdiploidy) and the other by structural changes (nonhyperdiploidy), most commonly involving translocations of the IGH gene, located at 14q32.
The HIV-1 Tat protein has been recently explored as a prospective vaccine candidate with broad, subtype non-specific action.
It has been observed that individuals who have recovered from influenza infections develop broad subtype-specific immunity that can protect them from subsequent infection by closely related drift variants of the same subtype [10], [11], [12].
