Sentence examples for broader selectivity from inspiring English sources

The EGFR inhibitor lapatinib was one of the first nearly monospecific kinase inhibitors [39]; others may have much broader selectivity profiles [40].

The ab6A ORN shows a somewhat broader selectivity characteristic: activators are not as easy to discriminate from non-activators as for the other ORNs, and our method of assigning binary activity values may not have been appropriate in this case.

A series of designed molecules were prepared and screened initially for inhibitions of MMP-2 and MMP-9, respectively, as these are designed followed by other MMPs to observe the broader selectivity.

One member of the conantokin family, conantokin (con -G, a 17-residue peptide, is selecon -Gfor NMDaRs containing the N-methyl-d-aspartate receptor subunit 2 B (NR2B), whereas the homologous peptides, con-T and con-R, show broader selectivity for NR2 subunits.

The spacing at the narrowest region of the pore (the aromatic/arginine ring) is significantly wider in GlpF [3.4 Å (Nollert et al. 2001)] compared with AQP1 [2.8 Å in AQP1 (Sui et al. 2001)], which accounts for the broader selectivity of the aquaglyceroporin.

The first-generation PI3K inhibitors targeted all PI3K isoforms, but have been limited by toxicity due to the broad selectivity profile.

Mass spectrometric profiling revealed that most DUBs examined have broad selectivity, whereas a subset displays a clear preference for recognizing noncanonical over K48/K63 Ub linkages.

If an RF amplifier is used, it will have a low gain (3 to 20 dB) and relative broad selectivity (maybe a wideband amplifier).

Therefore, the low energy consumption, broad selectivity in ink and substrate, and continuous writing capability are still technical challenges for a general realization of the existing additive nanofabrication methods.

We have selected BCL for our study because of numerous experimental results available, but also because of its broad selectivity and stability that makes it interesting for industrial use.

The hypothesis that cytochrome-oxidase (CO) expression in the cortex could be caused by the clustering of cells with broad selectivity has been considered in the past [98] [101].