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Genes with HCP were expressed in a broader range of tissues, and were associated using GO analysis with housekeeping functions, whereas genes in the LCP group were enriched in tissue-specific functions.
HPAI also differs from LPAI in that the former has more amino acids adjacent to the hemagglutinin cleavage site, which allows it to replicate in a broader range of tissues [for details, see [ 2, 22]].
Of the two variants, rs10876864 had strong cis and trans associations in a broader range of tissues, and aligned with histone signatures and >25 ChIP-seq binding signals [Additional file 6].
These are strong signals that lead us to hypothesize that the carcinogenic potential of oxalate is specific for breast tissue, although more experiments with a broader range of tissues are needed to confirm this.
This discrepancy is probably caused by the insufficiency of the pqe-1 promoter regions that we used to examine the expression pattern of pqe-1 ; pqe-1 may be actually expressed in many other tissues, and in that case the pqe-1 mutations may have effects in a broader range of tissues than we have assumed.
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Future work may benefit from T1 mapping of the brain [31] since this will be sensitive to a broader range of tissue manganese concentrations while being unaffected by receive-coil artifacts – the primary motive for normalizing signal intensities in the present study.
Second, the cutting fluence can be increased substantially above threshold without affecting the focal position making it possible to handle a broader range of tissue conditions.
The CYYR1 messenger RNA was found by Northern blot analysis in a broad range of tissues (two transcripts of 3.4 and 2.2 kb).
Collagen- and glycosaminoglycan (GAG -based tissue matrices have been popularized due to their bioloGAG -baseduitissuea broad range of tissues and the ability to tune structure and matricesal properties thavegh a variety of processes.
While it is widely accepted that in vivo mutation assays are more relevant to the human condition than are in vitro assays, our ability to evaluate mutagenesis in vivo in a broad range of tissues has historically been quite limited.
"Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis," said Healy.
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