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Importantly, IKDCs have a more potent anti-tumor effect than NK cells, and have a broader range of target cells and prevent tumor outgrowth more effectively [ 15].
The aly-class genes (aly, comr, tomb, topi and achi/vis) are required for expression of a broader range of target genes than the can-class genes (can, mia, nht, rye and sa).
However, due to the highly conservative criteria used and other technical limitations discussed earlier, this is most likely an underestimate of the true degree of differential binding, which may affect a broader range of target genes and account for many of the more subtle changes in gene expression.
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Last fall, as the United States began preparations for a possible war against Iraq, Secretary of Defense Donald H. Rumsfeld authorized pilots to attack a broader range of targets, as well as to conduct mock bombing runs on likely Iraqi targets.
Airbrushing was safer, 10-fold faster, 100-fold less expensive to set-up and able to deposit nanofibers onto a broader range of targets than electrospinning.
More DNA aptazyme sensors for a broader range of targets could be developed by this general approach as long as suitable DNAzymes and aptamers are used.
To assess whether the SAM technology could be used for a broader range of targets, we investigated the immunogenicity and efficacy of SAM vaccines expressing antigens from Group A (GAS) and Group B (GBS) Streptococci, as models of bacterial pathogens.
This hypothesis is supported to some extent by the observation that the placebo group also experienced small increases in apparent antibody titers using the MN assay, which can also detect antibodies to a broader range of targets than just HA.
Over the past two decades GC-MS, LC-MS and LC-MS/MS methods have all been used to detect, identify and quantify oxylipins and other polar metabolites, however the latter approach is associated with simpler sample workup strategies and can simultaneously assess a broader range of targets [83].
Thus, MuRF1/2 recognize a broader range of targets than detected previously.
This technology enables the study of a broader range of targets, including preclinical candidates, facilitating determination of polymorphism propensity much earlier in the drug development process.
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