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Because MHC alleles are expressed codominantly, MHC heterozygotes should be able to detect a broader range of pathogens than homozygotes [12], [16], [17].
gambiae system, suggesting that PRS1 is involved in biological processes exploited, or selected by a broader range of pathogens or parasites, which An.gambiae adult or larvae can encounter.
Because they need to cope with a broader range of pathogens with limited resources, some efficient signaling structures are reduplicate.
In addition to these microarrays, which have a spectrum of identification limited to a few viral species, major microarray platforms were developed for the detection of a much broader range of pathogens [ 12- 17].
Furthermore, a bow-tie structure was observed and considered as a core system mediating the input pathological factors and the output host responses for efficient processing of a broader range of pathogens with limited proteins and pathways, suggesting the robustness of the network.
Heterozygote advantage acts when individuals who are heterozygous at a given locus have a higher fitness than individuals who are homozygous because they can bind a larger suite of antigens and confer resistance to a broader range of pathogens (Doherty and Zinkernagel 1975).
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From a theoretical point of view, Doherty and Zinkernagel (1975) suggested that Mhc heterozygotes should exhibit the highest immunocompetence (the 'heterozygote advantage' HA hypothesis), in terms of the recognition and elimination of pathogens, because such individuals could present a broader range of pathogen-derived peptides.
We have the broadest range of pathogens and environmental risks that are tested for of any laboratory in the world.
Antimicrobial peptides (AMPs) are a class of host-defense molecules that neutralize a broad range of pathogens.
Frogs share common regulatory and immune systems with humans and other higher order organisms — because of this it's possible to screen through their embryos for a broad range of pathogens and thousands of potential therapeutic compounds much faster than using other experimental models.
It is feasible to construct a biodefense platform combining synergistic agents that activate the innate immune system against a broad range of pathogens on the basis of conserved microbial components by using a nasal spray for immune activation in the respiratory and gastrointestinal tracts because these are the most likely routes of attack.
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