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Additional advantages of combined RAF and MEK inhibition were the broader range of efficacy exhibited across melanoma cell lines and the ability to overcome vemurafenib drug resistance.
Newly designed peptides with decreased toxicity and a broader range of efficacy may have the potential to provide significant improvements in the treatment of infections.
Itraconazole has a broader range of efficacy in comparison to fluconazole, which includes Aspergillus spp. and other rare mold infections [ 18– 20].
These newly designed synthetic anti-lipopolysaccharide peptides (SALPs) with decreased toxicity and a broader range of efficacy are able to neutralize LPS-mediated effects at different degrees in vitro as well as in vivo [ 4, 7].
Thus, we compared three newly developed synthetic anti-lipopolysaccharide peptides (SALPs) with a broader range of efficacy to suppress cytokine release in plasma and CD14 mRNA expression in organ tissue in a murine, polymicrobial sepsis model.
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However, detailed examination of 474 individual protected areas unveils a broad range of efficacy.
While models can be fit to a broad range of efficacy measures, this paper illustrates the advantages of using continuous outcome measures compared to binary outcome measures.
The strengths of this study include the randomized, placebo-controlled trial design and the broad range of efficacy and safety measures employed.
The function of GPCRs can be modulated by a variety of ligands with a broad range of efficacies, often in a signaling pathway specific manner.
To assess whether the SAM technology could be used for a broader range of targets, we investigated the immunogenicity and efficacy of SAM vaccines expressing antigens from Group A (GAS) and Group B (GBS) Streptococci, as models of bacterial pathogens.
In transfusion medicine, however, decisions are based on a broader range of inputs, and the criteria for evaluating the efficacy and/or cost-effectiveness of proposed interventions differ from those used in other areas.
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