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Within the skin, GPNMB/OA has been proposed to be expressed specifically in melanocytes [9], while others suggest a broader pattern of expression that includes keratinocytes, melanocytes and Langerhans cells [7].
Nrp1 showed a broader pattern of expression, although within the brain parenchyma Nrp1 mRNA was present most notably in blood vessels (Fig. S6B-C).
Even though the majority of β-gal-positive cells co-stained with this putative stem cell marker, Msi-1 displayed a broader pattern of expression that extended into the TA-cell region.
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RNA analysis revealed that although several APOBEC3s can be expressed in individual breast cancer cell-lines, the highest and broadest pattern of expression was evident with APOBEC3B.
The second group of embryos displayed a broad pattern of expression with the strongest signal in the middle part of the PSM (Figure 1D, n = 36/104, phase II).
First, they show a very broad pattern of expression, including numerous tissues and organs [3], [6], [7], [8], whereas α, β and γ mRNAs expression is mainly restricted to epidermis.
We show that one unifying feature of the methylated genes in this species is their broad pattern of expression and the associated 'housekeeping' roles.
One unifying theme of the honey bee methylome is the broad pattern of expression of methylated genes indicating that gene activities required for the core cellular functions might be controlled, at least partly, by epigenetic means.
Such a mechanism is suggested by previous findings [ 11] that TICs have a broad pattern of expression across multiple samples, in contrast with other types of gene fusions that tend to have a restricted pattern of expression in particular samples.
Moreover, according to our initial phylogenetic analyses, the echinoderm sequences clustered with those from mammals and the epd transcript showed a broad pattern of expression in echinoderm tissues [ 12].
Even with that caveat, the fact is that results very similar to those found in mouse are observed for UBQLN2 (i. e. a broad pattern of expression, with high level in nervous system samples and low levels in testis) and UBLQN3 (testis-specific expression, which is confirmed also by independent results [ 8]).
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